American Board of Family Medicine (ABFM) Exam 2025 – 400 Free Practice Questions to Pass the Exam

Bupropion is contraindicated in individuals with seizure disorders because it can lower the seizure threshold, increasing the risk of seizures. This is particularly relevant in patients who already have conditions that predispose them to seizures. The pharmacological action of bupropion, which primarily involves the inhibition of norepinephrine and dopamine reuptake, may provoke seizures in susceptible individuals, especially if they have pre-existing seizure disorders or if the dosage exceeds the recommended levels.

While hypertension is a concern with bupropion, it is not a strict contraindication unless it is poorly controlled. Chronic pain conditions may require careful consideration but do not generally preclude the use of bupropion. Diabetes mellitus can be managed safely with bupropion, making it an option for patients with this condition. Therefore, seizure disorders represent a significant risk that directly contraindicates the use of bupropion.